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Biotech Startup

Section: New Tools, Products and Technologies     View all sections

11 Startups Using Quantum Theory To Accelerate Drug Discovery

   by Andrii Buvailo    4094
11 Startups Using Quantum Theory To Accelerate Drug Discovery

Molecular mechanics (MM) is a traditional computational approach when it comes to modeling in synthetic organic chemistry, medicinal chemistry and versatile aspects of drug design. However, MM methods have significant limitations, for example, when used to study electron-based properties within the drug-receptor microenvironment. Quantum mechanical (QM) methods allow to substantially increase the accuracy of predictions and provide much more relevant models of chemical and biological objects and their interactions, but QM methods are extremely (often prohibitively) computationally costly.

However, a series of advancements over recent years allowed to expand horizons in this direction, for example, the emergence of density functional theory (DFT), the overall increase in the computation power and the emergence of distributed cloud-based computational infrastructures.

Copenhagen-based Biotech Pcovery To Extend Collaboration With Enamine

   by Andrii Buvailo    3425

Founded in 2009, Pcovery is a Danish biotech startup company involved in drug discovery to fight invasive fungal infections. On November 22, 2016 Pcovery announced the extension of collaboration with a leading producer of building blocks and screening libraries -- Enamine Ltd. In the ongoing drug discovery program, Pcovery will utilize Enamine’s experience in synthesis of small compound libraries and singletons, route scouting, process optimization, and scale-up of lead compounds.