Where you find opportunities to grow

* Can't find your brand, product, service? Join BPT Marketplace

Latest Posts

In The Spotlight

The Overview of AI in Drug Discovery in 2019: The “Proof-of-concept Year”

The Overview of AI in Drug Discovery in 2019: The “Proof-of-concept Year”

The race for adopting new machine learning (ML), deep learning (DL) and related technologies (for simplicity -- “artificial intellige… read more

Upcoming Events

Featured Posts

The Evolving Pharma R&D Outsourcing Industry: A Bird’s-eye View

The Evolving Pharma R&D Outsourcing Industry: A Bird’s-eye View

Pharmaceutical companies are increasingly outsourcing their R&D activities, including early-stage research programs, to third party organizations -- academic institutions, biotech startups, and private contract research organizations (CROs) -- as a means to stay competitive, flexible, and profitable against all odds.   

Economically, there are factors such as increasing downward pressure on drug pricing by governments, an impending “patent cliff” threatening $198 billion worth of sales during 2019-2024), and downturns in income due to the increasing competition from generics and biosimilars. 

From the innovation's point of view, there is a boom in life sciences, stimulating the emergence of novel biological targets, therapeutic modalities, and even whole new areas of drug discovery -- adding opportunities, but also complexity and uncertainty to research programs. In fact, according to Deloitte’s report, return on late-stage pipelines dropped for the top 12 pharma companies from 10.1% in 2010 down to 3.7% in 2016.

Technologically, there is an unfolding “digital revolution”, bringing even further complexity and investment cost to the table -- in a form of artificial intelligence (AI), data mining and big data technologies, data-driven diagnostics, and digital health. 

Finally, the rise of the personalized medicine paradigm forces companies to rethink their research pipelines and “one-size-fits-all” product development programs, as well as reconsider their market strategies. 

A Race For Better Gene Editing Tech Is On

A Race For Better Gene Editing Tech Is On

A transformative technology for gene editing - clustered regularly interspaced short palindromic repeats (CRISPR) -- has become ubiquitous, at least in research laboratories, where scientists efficiently adopted CRISPR technology to manipulate genes of interest. Still, applying it for humans is associated with greater risks and faces ethical issues. However, alongside a too reckless experiment of a Chinese scientist who edited babies’ genomes, plenty of companies have made well-thought progress toward transferring gene editing technologies into the clinic. Here we make a brief but pithy review on up-to-date gene editing approaches and start-up companies active in this area.

[Interview] The Rise of Quantum Physics in Drug Discovery

[Interview] The Rise of Quantum Physics in Drug Discovery

Computer-aided drug design (CADD) is a central part of so-called “rational drug design”, pioneered in the last century by companies like Vertex. Over the last decades, CADD had great influence on the way new therapeutics are discovered, however, it also showed limitations due to modest accuracy of computational tools.  

The majority of software tools used for computational chemistry and biology rely on molecular mechanics -- a simplified representation of molecules, essentially reducing them down to “balls and sticks”: atoms and bonds between them. In this way it is easier to compute, but accuracy suffers greatly.

In order to gain adequate accuracy, one has to account for the electronic behavior of atoms and molecules, i.e. consider subatomic particles -- electrons and protons. This is what quantum mechanical (QM) methods are all about -- and the theory is not new, dating back to the early decades of the 20th century.  

Press Releases

Interviews with experts

[Interview] How COVID-19 Catalyzed AI-assisted Open Science Drug Discovery

[Interview] How COVID-19 Catalyzed AI-assisted Open Science Drug Discovery

Biopharma companies are now racing to find much-needed cures against SARS-CoV-2, a virus that caused the largest global pandemic of our time. One notable effort is the COVID Moonshot project, organized by an international consortium of scientists from academia, biotechs, contract research organizations (CROs), and pharma -- all working pro bono or via crowdfunding, philanthropy, and grants. 

The aim of the project is to rapidly develop easily manufacturable antiviral drugs that can inhibit the SARS-CoV-2 main protease, which is believed to be an Achilles heel of the coronavirus. The project is managed by PostEra, a startup company that uses artificial intelligence (AI) algorithms to map routes for chemical synthesis to speed the drug-discovery process.

[Interview] Advancing Off-the-shelf Cellular Medicines to Fight COVID-19

[Interview] Advancing Off-the-shelf Cellular Medicines to Fight COVID-19

Mesoblast Limited (Nasdaq:MESO; ASX:MSB), a world leader in developing allogeneic (off-the-shelf) cellular medicines, just announced that the first COVID-19 infected patients have been dosed with remestemcel-L, the company’s proprietary allogeneic cellular medicine. This study is conducted within the framework of the 300-patient randomized placebo-controlled Phase 3 trial underway in North America which focuses on patients with moderate to severe acute respiratory distress syndrome (ARDS) on ventilator support.

[Interview] Hacking Metabolomics With AI To Improve Clinical Research

[Interview] Hacking Metabolomics With AI To Improve Clinical Research

Personalized medicine has become a paradigm-shifting trend in healthcare - the hegemony of  “one-size-fits-all” drugs is increasingly challenged by novel innovative modalities and therapies, laser-sharped for a specific group of patients, or even a single patient in some cases. This is a complex story, and the progress in personalized medicine will take time and tectonic shifts in the pharmaceutical research workflow. 

On the other hand, the advent of personalized medicine is only possible with a more personalized system for health assessment, new robust biomarkers, and novel approaches to run and monitor clinical trials. This will require diagnostics that can provide sufficient insight into the metabolic status of individuals, and relatively new science of metabolomics is now taking off in the biotech industry.  

Editor's Pick: A Video Blog

How AI Is Applied To Metabolomics To Identify New Targets And Drugs

   by Andrii Buvailo    4464
How AI Is Applied To Metabolomics To Identify New Targets And Drugs

The team at MIT created the most comprehensive database of metabolites, their interactions with proteins, protein-protein interactions, drug-protein interactions, and associations of metabolites with diseases. They then use the obtained interactions map to make inferences about the disease mechanisms and novel targets. With this new technology, the team launched a biotech startup ReviveMed in 2016 having raised $1.5M of funding so far.

Network Driven Drug Discovery Using AI

   by Andrii Buvailo    3689
Network Driven Drug Discovery Using AI

“One-target-one-disease” paradigm has been around for decades, prompting numerous drug discovery programs focusing on identifying small molecules for targeting only one specific protein (or other targets) believed to be responsible for the disease mechanism.

Evaxion Biotech Uses AI To Develop Anticancer And Antimicrobial Vaccines

   by BiopharmaTrend    3758
Evaxion Biotech Uses AI To Develop Anticancer And Antimicrobial Vaccines

This is an interview with Niels Iversen Møller, a CEO, and Co-founder of Evaxion Biotech -- an immuno-informatics biotech from Denmark.

Evaxion Biotech uses its machine learning-based platform to compare DNAs of tumor cells and DNAs healthy cells and identify mutations that are critical for the disease. This data is further used to design anticancer vaccines.

View all videos

Trending Topics

Artificial Intelligence Machine Learning Small Molecules Biopharma news In Silico Pharmaceutical industry trends Biotech Startup Big Data MedChem Interviews coronavirus R&D Outsourcing Database Healthcare Antibiotics CROs