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ConstruQt - a Reliable Molecular Structure Predictor in the Cloud

   by Peter Jarowski    59
ConstruQt - a Reliable Molecular Structure Predictor in the Cloud

Since August Kekulé’s proposal for the tetrahedral configuration of carbon or his more famous realization that benzene was a cyclic molecule, a snake biting its tale, molecular structure has been the leading consideration for the design of new molecules as drugs or performance materials. For the former, it is said that 70% of drug design is based on molecular shape with the remainder attributed to electrostatic or non-bonded interactions.

Structural chemistry began around the 1860 with these dual assignments by Kekulé but it wasn’t until one hundred years later with Allinger’s initial force field approaches that the first classical molecular mechanics (MM) models became available to make computer-assisted prediction of molecular structure. These models themselves are based on principles derived by Robert Hooke, a contemporary of Isaac Newton, in the mid 17th century with additional layers from van der Waals (19th century) etc.

13 Useful Mobile Apps For Life Scientists

   by Andrii Buvailo    6772
13 Useful Mobile Apps For Life Scientists

(Updated: 10.09.2018)

Nowadays mobile devices are ubiquitous with an estimated number of smartphones and tablet PCs to exceed two billion globally.

The availability of internet connection in most public places, powerful processors, and user-friendly touch screen technologies make mobile devices useful not only for spare time activities but also for education and science.

Specialized mobile apps are ubiquitous in the area of healthcare providing value for medical doctors, as well as patients involved in various healthcare programs and therapies. Those include various apps for assisting clinical decision making by doctors, apps for monitoring physiological parameters of patients in real time, apps for managing doctor-patient interactions, apps for self-monitoring various health conditions and physiological parameters (for example, did you know you can identify a dangerous wart on your body using your mobile phone?) etc.  

19 Online Marketplaces Facilitating Life Science Research

   by Andrii Buvailo    9897
19 Online Marketplaces Facilitating Life Science Research

(Last updated: 23.08.2018)

Online marketplaces are websites with a “many-to-many” business logic. They can host multiple suppliers trading with multiple buyers via different e-commerce tools available as a part of a website functionality.

Why are online marketplaces great?

Online marketplaces can provide a substantial added value to its users. For example, buyers can quickly compare and select better offerings without the need to research multiple websites and surf online for price comparisons or product specifications. Additionally, marketplaces bring more transparency, trust, and standardization to the whole process of sourcing.

Navigating In REAL Chemical Space To Find Novel Medicines (Now 3.8 Billion Molecules)

   by Andrii Buvailo    2203
Navigating In REAL Chemical Space To Find Novel Medicines (Now 3.8 Billion Molecules)

[Latest update: 27.07.2018]

February 6 2018 will be marked in history as the day when an automobile embarked on a million year trip into far space. On that day, Falcon Heavy, the 230ft megarocket, successfully launched from Cape Canaveral, Florida, bringing on board Elon Musk’s personal Tesla Roadster with a crash test dummy called 'Starman' strapped into the driver's seat.

"The imagery of it is something that's going to get people excited around the world." says Elon Musk, a guy who literally revolutionized the area of space travel having developed and successfully tested first reusable rockets in the aerospace history, opening new horizons for cosmos explorations.

While advances in aeronautics are making news headlines daily, a much quieter scientific revolution is also happening in the area of “chemical space” explorations -- the one which might soon uncover novel medicines to cure diseases.

36 Web Resources For Target Hunting In Drug Discovery

   by Alfred Ajami, Andrii Buvailo    7776

Choosing the right biological target or a combination of targets is a fundamental task for any successful drug discovery project. All the subsequent efforts -- be it a small molecule hit identification, lead optimization, pharmacokinetic studies, or a clinical trial -- will just be as effective, at the end of the day, as was the initial decision to choose one target or another.