A Landscape of Artificial Intelligence (AI) In Pharmaceutical R&D

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Antibiotics


How To Be Ready For Future Pandemics?

   by Andrii Buvailo    876
How To Be Ready For Future Pandemics?

What do antibiotic-resistant bacteria (“superbugs”) and coronaviruses have in common? They both can kill lots of people globally, and they both have been commercially unattractive targets for the pharma business for too long.

 

FDA Analysis of Antibiotic Development - with Hubris!

   by David Shlaes    455
FDA Analysis of Antibiotic Development - with Hubris!
(This post originally appeared on David Shlaes's personal blog)
 
The US FDA just published an analysis of antibiotic development looking back over the last 40 years. The paper was accompanied by an editorial by Rex and Outterson. These papers are well worth reading and I highly recommend them for everyone whether they are familiar with antibiotic development or not. I must say that the hubris of the FDA analysis is astounding (see below). 

Antibiotic Research and Development - Public vs. Private Funding

   by David Shlaes    1024
Antibiotic Research and Development - Public vs. Private Funding

Over the past decade, pull incentives as a solution to the broken antibiotic market have been proposed to entice companies into antibiotic research and development.  These incentives would essentially provide a market, and therefore a return on investment for pharmaceutical companies. Almost all of today’s inadequate antibiotic pipeline is provided by biotech and small pharma.  All are threatened with loss of investor interest because of the failed marketplace and many are experiencing difficulty in raising funds either from public or private markets.  One alternative to providing money to the “evil” pharmaceutical industry via a substantial pull incentive is to create publicly funded non-profit organizations or public-private ventures that would essentially replace the industry in antibiotic research, development and commercialization. Two proponents of this approach are Lord Jim O’Neill (of the O’Neill Commission or Antimicrobial Resistance Review fame) and Ramanan Laxminarayan of the Center for Disease Dynamics, Economics and Policy and of GARDP. Both, clearly, are key thought leaders in the area. 

"Hot" Research Areas in Drug Discovery - 2019

   by Andrii Buvailo    6717
"Hot" Research Areas in Drug Discovery - 2019

Things like gene editing, stem cells, immunotherapies and new types of biologics are now mega-trends in the pharmaceutical industry, widely covered in media, and I guess there is little doubt that biology is the next big thing in medicine. However, in this post I would like to outline several hot areas in small molecule drug discovery, suggesting a lot of untapped potential and investment prospects in this more “traditional” pharmaceutical research space.