In a case of "back to the future", chemists at Scripps collaborating with instrument engineers at IKA have unveiled a powerful tool for electrifying chemistry to achieve complex reactions. The ElectraSyn is expected to change approaches to 3D-molecules, late-stage derivatization, and focused library construction, while promoting environmentally conscious chemistry. The teaser graphic here is from Ref. 5 in the text that follows.
Boston-based LifeMine Therapeutics, a fresh new drug discovery startup, just announced a $55 million Series A financing from a number of life sciences investors, including WuXi Healthcare Ventures, Foresite Capital, GV (formerly Google Ventures), Arch Ventures, Boyu Capital, Blue Pool Capital, Merck Ventures, and Alexandria Venture Investments.
Virtual reality (VR) has been a hot topic in game industry lately, but now it finds its way to biopharmaceutical research. Novartis is exploring opportunities to leverage this new technology for the benefit of early-stage small molecule drug discovery research. Using VR researchers at Novartis are able to visualize protein targets and small molecules and explore interactions between them in a visual three-dimensional mode.
A multi-year research agreement has just been announced between Takeda Pharmaceuticals (TSE: 4502) and an Artificial Intelligence (AI)-driven computational drug design company Numerate, Inc. Under this contract, Numerate will have to come up with new clinical candidates in the Takeda’s core therapeutic areas: oncology, gastroenterology, and central nervous system disorders.
Scientists estimated that the human genome encodes above 20,000 different proteins in our body. However, available public databases contain records of known ligands for only about 10% of all proteins. Expanding the map of “druggable” proteins increases the chances of running into novel small molecule drugs.
A recent study, published in Cell, opens doors for unveiling novel drug targets and even reconsidering some of the known protein targets, previously tagged “undruggable”.