Since the early days of the pharmaceutical industry, small molecules have been the most extensively used group of drugs. Nowadays, up to 90% of the on-the-market therapeutics are small molecules, which can be explained by some of their unique features. Firstly, their size permits easy ingestion and distribution all over the body with a bloodstream allowing a convenient, non-invasive oral route of administration. Small molecules efficiently penetrate cell membranes to reach intracellular targets, exhibit a variety of action mechanisms due to their physicochemical properties and provide direct interaction with a target.
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