Database for network-based drug-repositioning

PROMISCUOUS is an exhaustive resource of protein-protein and drug-protein interactions with the aim of providing a uniform data set for drug repositioning and further analysis. Our database PROMISCUOUS contains three different types of entities: drugs, proteins and side-effects. These entities are connected between each other through drug-protein, protein-protein and drug-side-effect relations.

Proteins are retrieved from UniProt and are displayed with synonyms and organism information. Additional information as 3D-structures from PDB and EC-numbers are given if available. Drugs gained from SuperDrug were integrated to PROMISCUOUS and assigned metadata as ATC-codes (Anatomical Therapeutic Chemical), structure information and synonyms. The side-effects contained in the database were fetched from SIDER and related to the drugs.

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