Our metabolomic pipeline identifies all novel molecules in a given extract sample using high-throughput high-resolution LCMS, predicts additional chemical characteristics of those molecules, and use an automated workflow to isolate molecules that meet a development program’s parameters. Once isolated, candidate molecules can be assayed for bioactivity to identify hits for downstream development.

This can be done both on material from a pre-existing extract library or from material collected from new fermentations. Our in-house fermentation workflow utilizes high-throughput culturing to define media conditions that optimize natural target molecule production for scale-up, without the need for heterologous gene expression. Strain selection to hit molecule isolation and assay can be completed in approximately six weeks.