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AcuraStem

AcuraStem logo

Founded
2016
Geography
United States of America based
Funding
$6 M

AcuraStem is a fast growing startup company that was formed in 2016 to create an innovative precision medicine platform. We are a team of PhDs, professors, tech entrepreneurs, and successful drug company veterans employing the latest scientific breakthroughs to address one of the most challenging, but we believe tractable, health problems of our time — Amyotrophic Lateral Sclerosis (ALS). We are developing the best-in-class technology platform which consists of complex cellular models from ALS patient cells, and sophisticated assays which permit our scientists to model patient tissues in the laboratory. Using this advanced technology, we can evaluate the progression of disease and test existing FDA approved therapeutics or combinations of therapeutic approaches to find the most efficacious treatments to slow disease progression. AcuraStem has leveraged this platform to identify a novel target and preclinical lead candidate which we are advancing to the clinic. AcuraStem also provides access to this technology platform to commercial and academic partners so that they can evaluate their therapeutic candidates under development.

AcuraStem has developed a breakthrough precision medicine platform called iNeuroRx, which leverages patient stem cells and advanced machine learning technology to discover drugs for neurodegenerative diseases. AcuraStem has utilized this platform to identify innovative ALS targets and has generated a preclinical lead candidate (AS-1) that they are advancing to the clinic.

Technologies

AI Companies (Drug Discovery)  

R&D Platform

AcuraStem’s iNeuroRx® technology uses living motor neurons (muscle-controlling nerve cells) from many ALS patients as a tool for the identification and development of novel treatments, and also to assess how broadly acting the treatments will be in the patient population. Unlike the scientific avenues that informed or inspired prior approaches, AcuraStem’s therapeutic insights originate in patient cells and, bolstered by successful validation in animal models, have led to promising therapeutic candidates, which may stop disease progression in a majority of ALS patients.


iNeuroRx

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Pipelines

Patient-Based Drug Discovery Pipeline
Preclinical  |  Visit website

Although there is a high burden associated with nervous system disorders, development of new therapeutics remains stagnant with relatively low FDA approval rates (8.4 percent) as compared to other therapeutic areas. In particular, ALS and FTD drugs have an approval rate less than 1 percent. This is because these programs rely heavily on immortalized cell lines and animal models in pre-clinical development, and therefore do not:

- Identify the right targets
- Optimize drugs on relevant human tissues
- Select responsive patients for clinical trials

Products

 

Services

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