Andrew Lowerson

Contributor

Key Organics Limited – a Leading Provider of Chemistry Services, Analytical Services and BIONET Products to the global Life Science industries

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NSTDA-BIOTEC selects Key Organics BIONET Fragment Library to identify new non-pyrimidine inhibitors of malaria parasite Plasmodium falciparum dihydrofolate reductase (PfDHFR).

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NSTDA-BIOTEC selects Key Organics BIONET Fragment Library to identify new non-pyrimidine inhibitors of malaria parasite Plasmodium falciparum dihydrofolate reductase (PfDHFR).

In recent research at BIOTEC1 a three-step fragment-based screening of PfDHFR was undertaken employing Key Organics BIONET Premium library containing 1163 fragments. This library was chosen over other commercial ones as it is rule-of-three compliant and was curated from any PAINS and aggregating compounds. All fragments are also soluble at 200 mM in DMSO and display high diversity.