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Joanna Bowie

Contributor Featured Research

Joanna from Creative Biostructure who offers insightful strategies and cost-effective services on structure determination of macromolecules using X-ray Crystallography, EM, NMR, etc.

   

Drug Targets Antivirals

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Structural Basis of Poxvirus Transcription Revealed

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Structural Basis of Poxvirus Transcription Revealed

In order for viruses to proliferate, they usually need to be supported by infected cells. In many cases, the molecules they need to replicate their own genetic material are only found in the nucleus of the host cell before infecting other cells in the vicinity. But not all viruses enter the nucleus. Some viruses stay in the cytoplasm and must therefore be able to replicate their genetic material independently. To do so, they must bring their own "machined parts". A key player in this process is a specialized enzyme, RNA polymerase, composed of various subunits. This enzyme reads genetic information from the viral genome and transcribes it into messenger RNA (mRNA) and uses mRNA as a blueprint for proteins encoded in the genome.