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This company is included in Intelligence Lab

Macomics

Macomics logo

Website
https://macomics.com/
Founded
2018

Macomics harnesses world-leading expertise in macrophage biology, which in combination with the company’s proprietary technology will provide insights into TAMs and the tumour microenvironment, and lead to therapeutic discoveries that will increase the body’s immune defence against tumours across various cancers.

R&D Platform

ENIGMAC™ incorporates novel assay systems, unique genome editing methods, supported by multi-omics bioinformatics analyses. We use a human Induced Pluripotent Stem Cell (iPSC) line that yields macrophages phenotypically and functionally very similar to HUMAN monocyte-derived macrophages (MDM). By employing this iPSC system we can produce millions of macrophages per week, which allows multiple high throughput assays to support target validation and drug discovery. In addition, we have developed a suite of technologies to allow fast and reliable gene editing of macrophages. Our proprietary toolbox allows us to perform gene Knock In (KI), Knock Out (KO) and Knock Down (KD) with high efficiency both at iPSC and macrophage level while maintaining expression/silencing during macrophage differentiation. KD can be performed using a pooled approach that enables screening by flow cytometry-based phenotypes at large scale.

News

  • 2023-04-19
    Macomics Unveils ENIGMAC™ Discovery Platform at AACR for Target Validation in Macrophage Therapies

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