Chris De Savi

Vice President, Head of Drug Discovery at Kymera Therapeutics  


As Vice President, Head of Drug Discovery at Kymera Therapeutics, Chris is responsible for medicinal and computational chemistry, lead discovery (biochemistry, biophysics, structural biology), pre-clinical development (DMPK and Toxicology) and proteomics. His team contributes to all drug discovery phases at Kymera from project inception through to clinical candidate discovery and beyond. Prior to joining Kymera, Chris was head of chemistry at Blueprint Medicines, a precision medicine company specialized in kinase drug discovery and development. Chris has deep experience in leading discovery research groups and project teams in both global pharmaceutical and biotech companies. He has directly contributed to the invention of 9 clinical candidate drugs for oncology and inflammation disease – most recently BLU-945, a EGFR T790M/C797S triple mutant inhibitor for the treatment of lung cancer, AZD4573, a selective CDK9 inhibitor for the treatment of haematological malignancies and AZD9496, an oral, selective estrogen receptor degrader for the treatment of ER+ breast cancer. He co-discovered Barasertib (AZD1152), a selective Inhibitor of Aurora B kinase for the treatment of AML. He is an author of over 50 peer-reviewed publications and patents in the fields of medicinal chemistry and drug discovery and a PhD qualified chemist who has previously held academic positions at Queens’ College Cambridge and University of Cambridge, Cambridge, UK.

Contributing Author   in
Bioeconomy & Society   Novel Therapeutics  

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Latest articles from Chris


Transformational EGFR Drug Discovery

  
Transformational EGFR Drug Discovery

Lung cancer accounted for 18% of deaths caused by cancer in 2020, making it the leading cause of cancer mortality globally.

Non-small-cell lung cancer (NSCLC) accounts for the majority of these cases (80−85%), and mutations in the kinase domain of …

Tissue Selective E3 Ligase-based Degraders

  
Tissue Selective E3 Ligase-based Degraders

The efficacy and selectivity of protein degrader drugs depend on their affinity to the target protein but also on the type of E3 ubiquitin ligase (E3) that is recruited to trigger proteasomal degradation. The arsenal of E3s that can be hijacked for targeted …

Anticipated Drug Approvals 2022

  
Anticipated Drug Approvals 2022

Drug Discovery crystal ball gazing for the year ahead. And the hottest prospects are discussed below.

We already have 5 CDER (FDA) approvals this year which are tantalizing new treatments for patients -

  1. Daridorexant (Quviviq), a selective dual antagonist of the orexin receptors OX1 and OX2 used for …

Are We Keeping Up With Antimicrobial Resistance?

  
Are We Keeping Up With Antimicrobial Resistance?

Antimicrobial resistance (AMR) poses a major threat to human health.

There were an estimated 4.95M deaths associated with bacterial AMR in 2019, including 1.27M deaths attributable to bacterial AMR.

Lower respiratory infections accounted for more than 1.5M deaths associated with …

Breakthrough Medicines 2021

  
Breakthrough Medicines 2021

It has been a momentous year of innovation for drug discovery while the world is still facing the deadliest pandemic in its history. Below is highlighted some of the most impactful breakthrough medicines. These approved or emerging treatments will have a …