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Shape Therapeutics

Shape Therapeutics logo

Website
https://www.shapetx.com/
Founded
2018
Patents
31
Publications
10

Technologies

CRISPR Startups Gene Therapy Startups RNA-focused Startups

Shape Therapeutics (ShapeTx) is a development-stage biotechnology company establishing itself as the leader in next-generation gene therapy. Our novel technology platform enables direct in vivo targeting/modification of RNA by leveraging ADARs (Adenosine Deaminase Acting on RNA), suppressor tRNAs, and immune-stealth adeno-associated viruses (AAVs).

ShapeTx is providing solutions to many of the challenges that contemporary genome engineering technologies face (like CRISPR, TALENs, etc.), such as permanent off-target damage, high risk of immunogenicity and therefore low in vivo applicability as effective gene therapy approaches. ShapeTx’s technology instead engages natural human cellular machinery to target RNA with high in vivo efficiency.


Posts Mentioning This Company

7 Promising RNA Biotech Companies To Watch in 2024

June 16, 2024  
For many years the focus of therapeutic developments and scientific research was directed at the genome and proteins. Yet, there is a completely different level of cell regulation – transcriptome level, presented by Ribonucleic acids (RNAs). RNA molecules are not just intermediates between DNA and proteins, in fact, they also carry …

14 Cutting-Edge Startups Focusing On RNA Research

May 29, 2024  
For many years, the focus of therapeutic developments and scientific research was directed at the genome and proteins. Yet, there is a completely different level of cell regulation: the transcriptome level, presented by ribonucleic acids (RNAs).
Top Companies At The Forefront Of RNA Therapeutics Development

Top Companies At The Forefront Of RNA Therapeutics Development

March 4, 2020  
Alongside the topic of gene editing technologies that keeps making headlines these days, there is also a wave of breakthroughs in the field of RNA-targeting medicines, primarily falling into the following two categories: antisense oligonucleotides (ASO), and RNA interference (RNAi) technologies. (another promising approach, dealing with editing RNA itself by …
A Race For Better Gene Editing Tech Is On

A Race For Better Gene Editing Tech Is On

Feb. 19, 2020  
A transformative technology for gene editing - clustered regularly interspaced short palindromic repeats (CRISPR) -- has become ubiquitous, at least in research laboratories, where scientists efficiently adopted CRISPR technology to manipulate genes of interest. Still, applying it for humans is associated with greater risks and faces ethical issues. However, alongside …
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ThermoFisher Scientific: Integrated genetic technologies for cell therapy development
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