Guiding drug discovery with proprietary high throughput 3D patient cell technology and genomics will drastically increase the success of novel drug candidates and directly result in faster development at reduced costs. SEngine Precision Medicine’s innovative approach brings diagnostics, drug discovery and artificial intelligence together with our patient-derived 3D tumor organoids to identify translational biomarkers and develop new cancer-fighting drugs.

Taking Aim at Cancer’s Vulnerabilities

SEngine’s method uniquely targets currently undruggable oncogenic drivers by developing novel targeted therapies for ‘synthetic lethal’ vulnerabilities. A synthetic lethal target is a gene which is essential for optimal fitness of a cancer cell, but not for a normal cell, making it prime for new therapeutic solutions. Therapies targeting these specific vulnerabilities dramatically reduce toxicity, often sparing the patient harmful side effects. SEngine Precision Medicine is currently pursuing multiple targets including those that exploit vulnerabilities in the cancer-causing gene alterations in MYC, TP53 and KRAS, which are found in more than 60% of all tumors.