Subscribe Become an Author Log In

BiopharmaTrend.com

Covering emerging technologies, innovations, and companies

Biotech Startup


A Drug Repurposing Case By Biotech Startup Forty Seven Inc

   by Andrii Buvailo    2758
A Drug Repurposing Case By Biotech Startup Forty Seven Inc

Drug repositioning is a smart and cost-effective approach used by some pharmaceutical companies to re-invent their previously successful drugs in a new role and generate extra value from existing assets.   

Pharmaceutical companies find drug repurposing programs largely beneficial over usual drug development from scratch. because they allow saving money on R&D, toxicity tests and other different trials already conducted with a known drug. The risks of failure at a later stage of repurposed drug development are lower, therefore the whole project becomes more attractive from the investor’s point of view.

A Second Chance for Integrins: Biotech Startup Morphic Therapeutic Reinvents Old Target

   by Andrii Buvailo    1805
A Second Chance for Integrins: Biotech Startup Morphic Therapeutic Reinvents Old Target

Integrins are a group of transmembrane receptors playing a major role in cell-cell and cell-extracellular matrix (ECM) interactions. When triggered, integrin receptors transduce signals to the interior of the cell, providing quick and flexible “status update” about chemical composition and mechanical status of the ECM. It results in a cellular response, such as a change in the cell shape, regulation of the cell cycle, adjusting motility, or adding new receptors to the cell membrane.